publications

manuscripts

2020

Pisarevsky E, Blau R, Epshtein Y, Ben-Shushan D, Eldar-Boock A, Tiram G, Koshrovski-Michael S, Scomparin A, Pozzi S, Krivitsky A, Shenbach-Koltin G, Yeini E, Fridrich L, White R, Satchi-Fainaro R. Rational Design of Polyglutamic Acid Delivering an Optimized Combination of Drugs Targeting Mutated BRAF and MEK in Melanoma. Advanced Therapeutics, https://doi.org/10.1002/adtp.202000028, 2020.  [PDF] [Publisher]

2019

Zinger A, Koren L, Adir O, Poley M, Alyan M, Yaari Z, Noor N, Krinsky N, Simon A, Gibori H, Krayem M, Mumblat Y, Kasten S, Ofir S, Fridman E, Milman N, Lübtow MM, Liba L, Shklover J, Shainsky-Roitman J, Binenbaum Y, Hershkovitz D, Gil Z, Dvir T, Luxenhofer R, Satchi-Fainaro R, Schroeder A. Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors. ACS Nano. 2019 Sep 20. doi: 10.1021/acsnano.9b02395. [PDF] [PubMed]

Hananya N, Press O, Das A, Scomparin A, Satchi-Fainaro R, Sagi I, Shabat D. Persistent Chemiluminescent Glow of Phenoxy-Dioxetane Luminophore Enables Unique CRET-Based Detection of Proteases. Chemistry. 2019 Sep 8. doi: 10.1002/chem.201903489. [PDF] [PubMed] 

Doron H, Amer M, Ershaid N, Blazquez R, Shani O, Lahav TG, Cohen N, Adler O, Hakim Z, Pozzi S, Scomparin A, Cohen J, Yassin M, Monteran L, Grossman R, Tsarfaty G, Luxenburg C, Satchi-Fainaro R, Pukrop T, Erez N. Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis. Cell Rep. 2019 Aug 13;28(7):1785-1798. [PDF] [PubMed]

Malfanti A, Scomparin A, Pozzi S, Gibori H, Krivitsky A, Satchi-Fainaro R, Mastrotto F, Caliceti P, Salmaso S. Oligo-guanidyl targeted bioconjugates forming rod shaped polyplexes as a new nanoplatform for oligonucleotide delivery. J Control Release. 2019 Sep 28;310:58-73. [PDF] [PubMed]

Conniot J, Scomparin A, Peres C, Yeini E, Pozzi S, Matos AI, Kleiner R, Moura LIF, Zupančič E, Viana AS, Doron H, Gois PMP, Erez N, Jung S, Satchi-Fainaro R, Florindo HF. Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators. Nat Nanotechnol. 2019 Sep;14(9):891-901. [PDF] [PubMed]

Borberg E, Zverzhinetsky M, Krivitsky A, Kosloff A, Heifler O, Degabli G, Peretz Soroka H, Satchi-Fainaro R, Burstein L, Reuveni S, Diamant H, Krivitsky V, Patolsky F. Light-Controlled Selective Collection-and-Release of Biomolecules by an On-chip Nanostructured Device. Nano Lett. 2019 Sep 11;19(9):5868-5878. [PDF] [PubMed]

Florindo HF, Madi A, Satchi-Fainaro R. Challenges in the implementation of MIRIBEL criteria on nanobiomed manuscripts. Nat Nanotechnol. 2019 Jul;14(7):627-628. doi: 10.1038/s41565-019-0498-7. [PDF] [PubMed]

Malfanti A, Mastrotto F, Han Y, Král P, Balasso A, Scomparin A, Pozzi S, Satchi-Fainaro R, Salmaso S, Caliceti P. A novel oligo-guanidyl-PEG carrier forming rod-shaped polyplexes Mol. Pharmaceutics 2019 Apr 1;16(4):1678-1693. [PDF] [PubMed]

Gnaim S, Scomparin A, Eldar-Boock A, Bauer CR, Satchi-Fainaro R, Shabat D. Light emission enhancement by supramolecular complexation of chemiluminescence probes designed for bioimaging. Chem Sci. 2019 Jan 16;10(10):2945-2955.  [PDF] [PubMed]

2018

Zafir-Lavie I, Sherbo S, Goltsman H, Badinter F, Yeini E, Ofek P, Miari R, Tal O, Liran A, Shatil T, Krispel S, Shapir N, Neil GA, Benhar I, Panet A, Satchi-Fainaro R. Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases. J Control Release.2018 Oct 17;291:80-89. doi: 10.1016/j.jconrel.2018.10.017. [PDF] [PubMed]

Blau R, Epshtein Y, Tiram G, Pisarevsky E, Israeli S, Yeini E, Krivitsky A, Eldar-Boock A, Ben-Shushan D, Green O, Ben-Nun Y, Merquiol E, Schwartz H, Blum G, Erez N, Grossman R, Ram Z, Shabat D, Satchi-Fainaro R, Image-Guided Surgery Using Near-Infrared Turn-ON Fluorescent Nanoprobes for Precise Detection of Tumor Margins, Theranostics, Jun (13): 3437-3460 (2018). [PDF] [Publisher]

Sainz V, Moura LIF, Peres C, Matos AI, Viana AS, Wagner AM, Vela Ramirez JE, Barata T, Gaspar M, Brocchini S, Zloh M, Peppas NA, Satchi-Fainaro R, Florindo HF. α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effectin melanoma. Acta Biomater.  Acta Biomater. 2018 Aug;76:193-207. [PDF] [PubMed]

Tiram G*, Ferber S*, Ofek P, Eldar-Boock A, Ben-Shushan D, Yeini E, Krivitsky A, Blatt R, Almog N, Henkin J, Amsalem O, Yavin E, Cohen G, Lazarovici P, Lee JS, Ruppin E, Milyavsky M, Grossman R, Ram Z, Calderón M, Haag R, Satchi-Fainaro R. Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma. FASEB J. 2018 32:5835-5850 (2018). [PDF] [PubMed] 

Gnaim S, Scomparin A, Das S, Blau R, Satchi-Fainaro R, Shabat D. Direct Real-Time Monitoring of Prodrug Activation by Chemiluminescence. Angew Chem Int Ed Engl. 2018 Jul 16;57(29):9033-9037. [PDF] [PubMed]

Krivitsky A, Krivitsky V, Polyak D, Scomparin A, Eliyahu S, Gibori H, Yeini E, Pisarevsky E, Blau R, Satchi-Fainaro R. Molecular Weight-Dependent Activity of Aminated Poly(α)glutamates as siRNA Nanocarriers. Polymers. May 2018, 10(5), 548-570; [PDF] [Publisher]

Vossen LI*, Markovsky E*, Eldar-Boock A, Tschiche HR, Wedepohl S, Pisarevsky E, Satchi-Fainaro R, Calderón M. Pegylated Dendritic Polyglycerol Conjugate Targeting Ncam-Expressing Neuroblastoma:Limitations and Challenges. Nanomedicine. 2018 Jun;14(4):1169-1179. [PDF] [PubMed] 

Eilon-Shaffer T*, Roth-Konforti M*, Eldar-Boock A, Satchi-Fainaro R, Shabat D. ortho-Chlorination of phenoxy 1,2-dioxetane yields superior chemiluminescent probes for in vitro and in vivo imaging. Org Biomol Chem. 2018 Mar 7;16(10):1708-1712.  [PDF] [PubMed]

Zupančič E, Curato C, Kim JS, Yeini E, Porat Z, Viana AS, Globerson-Levin A, Waks T, Eshhar Z, Moreira JN, Satchi-Fainaro R, Eisenbach L, Jung S, Florindo HF. Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer. Nanomedicine. 2018 Apr;14(3):835-847. [PDF] [PubMed]

Gibori H, Eliyahu S, Krivitsky A, Ben-Shushan D, Epshtein Y, Tiram G, Blau R., Ofek P, Sang Lee J, Ruppin E, Landsman L., Barshack I, Golan T, Merquiol E.,Blum G, Satchi-Fainaro R. Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer. Nature Communications. 2018 Jan 2;9(1):16. [PDF] [PubMed]

Krivitsky A*, Polyak D*, Scomparin A*, Eliyahu S, Ofek P, Tiram G, Kalinski H, Avkin-Nachum S, Feiner Gracia N, Albertazzi L, Satchi-Fainaro R. Amphiphilic poly(α)glutamate polymeric micelles for systemic administration of siRNA to tumors. Nanomedicine. 2018 Feb;14(2):303-315 [PDF] [PubMed] 

* These authors contributed equaly to this work 

2017

Ferber S*, Tiram G*, Sousa-Herves A, Eldar-Boock A, Krivitsky A, Scomparin A, Yeini E, Ofek P, Ben-Shushan D, Vossen LI, Licha K, Grossman R, Ram Z, Henkin J4, Ruppin E, Auslander N, Haag R, Calderón M, Satchi-Fainaro R. Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome. Elife (2017) Oct 4;6. pii: e25281. [PDF] [PubMed]

Green O, Gnaim S, Blau R, Eldar-Boock A, Satchi-Fainaro R, Shabat D. Near-Infrared Dioxetane Luminophores with Direct Chemiluminescence Emission Mode. J Am Chem Soc. 2017 Sep 20;139(37):13243-13248. [PDF] [PubMed]

Hananya N, Green O, Blau R, Satchi-Fainaro R*. Shabat D*, A Highly-Efficient Chemiluminescence Probe for Detection of Singlet Oxygen in Living Cells. Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11793-11796. [PDF] [PubMed]

*Corresponding authors

Eldar-Boock A, Blau R, Ryppa C, Baabur-Cohen H, Many A, Vicent MJ, Kratz F, Sanchis J, Satchi-Fainaro R. Integrin-Targeted Nano-Sized Polymeric Systems for Paclitaxel Conjugation: A Comparative Study. J Drug Target. 2017 Nov – Dec;25(9-10):829-844. [PDF] [PubMed]

Markovsky E, Vax E, Ben-Shushan D, Eldar-Boock A, Shukrun R, Yeini E, Barshack I, Caspi R, Harari-Steinberg O, Pode-Shakked N, Dekel B, Satchi-Fainaro R. Wilms Tumor NCAM-Expressing Cancer Stem Cells as Potential Therapeutic Target for Polymeric Nanomedicine. Mol Cancer Ther. 2017 Nov;16(11):2462-2472. [PDF] [PubMed]

Ferguson EL, Scomparin A, Hailu H, Satchi-Fainaro R. HPMA Copolymer-phospholipase C and Dextrin-Phospholipase A2 as Model Triggers for Polymer Enzyme Liposome Therapy (PELT). J Drug Target. 2017 Nov – Dec;25(9-10):818-828. [PDF] [PubMed]

Zupančič E, Curato C, Paisana M, Rodrigues C, Porat Z, Viana AS, Afonso CAM, Pinto J, Gaspar R, Moreira JN, Satchi-Fainaro R, Jung S, Florindo HF. Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming. J Control Release. 2017 Jul 28;258:182-195. [PDF] [PubMed]

Markovsky E, Eldar-Boock A, Ben-Shushan D, Baabur-Cohen H, Yeini E, Pisarevsky E, Many A, Aviel-Ronen S, Barshack I, Satchi-Fainaro R. Targeting NCAM-expressing neuroblastoma with polymeric precision nanomedicine. J Control Release. 2017 Mar 10;249:162-172. [PDF] [PubMed]

2016

Alishekevitz D, Gingis-Velitski S, Kaidar-Person O, Gutter-Kapon L, Scherer SD, Raviv Z, Merquiol E, Ben-Nun Y, Miller V, Rachman-Tzemah C, Timaner M, Mumblat Y, Ilan N, Loven D, Hershkovitz D, Satchi-Fainaro R, Blum G, P Sleeman J, Vlodavsky I, Shaked Y. Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.Cell Rep. 2016 Oct 25;17(5):1344-1356. [PDF] [PubMed]

Hananya N, Eldar Boock A, Bauer CR, Satchi-Fainaro R, Shabat D. Remarkable Enhancement of Chemiluminescent Signal by Dioxetane-Fluorophore Conjugates: Turn-ON Chemiluminescence Probes with Color Modulation for Sensing and Imaging. J Am Chem Soc. 2016 Oct 12;138(40):13438-13446. [PDF] [PubMed] 

Shatsberg Z, Zhang X, Ofek P, Malhotra S, Krivitsky A, Scomparin A, Tiram G, Calderón M, Haag R, Satchi-Fainaro R. Functionalized nanogels carrying an anticancer microRNA for glioblastoma therapy. J Control Release. 2016 Aug 26;239:159-168. [PDF] [PubMed]

Gnaim S, Scomparin A, Li X, Baran PS, Rader C, Satchi-Fainaro R, Shabat D. Tagging the Untaggable: A Difluoroalkyl-Sulfinate Ketone-Based Reagent for Direct C-H Functionalization of Bioactive Heteroarenes. Bioconjug Chem. 2016 . 27(9):1965-71. [PDF] [PubMed]

Krivitsky A, Polyak D, Scomparin A, Eliyahu S, Ori A, Avkin Nachum S, Krivitsky V, Satchi-Fainaro R. Structure-function correlation of aminated poly(α)glutamate as siRNA nanocarriers. Biomacromolecules. 2016. 17(9):2787-2800  [PDF] [PubMed]

Baabur-Cohen H, Vossen L, Krüger HR, Eldar-Boock A, Yeini E, Landa-Rouben N, Tiram G, Wedepohl S, Markovsky E, Leor J, Calderón M, Satchi-Fainaro R. In vivo comparative study of distinct polymeric architectures bearing a combination of paclitaxel and doxorubicin at a synergistic ratio. J Control Release. 2016. 257:118-131. [PDF] [PubMed]

Polyak D, Krivitsky A, Scomparin A, Eliyahu S, Kalinski H, Avkin-Nachum S, Satchi-Fainaro R. Systemic delivery of siRNA by aminated poly(α)glutamate for the treatment of solid tumors. J Control Release. 2016; 257:132-143. [PDF] [PubMed]

Ofek P, Calderón M, Mehrabadi FS, Krivitsky A, Ferber S, Tiram G, Yerushalmi N, Kredo-Russo S, Grossman R, Ram Z, Haag R, Satchi-Fainaro R. Restoring the Oncosuppressor Activity of MicroRNA-34a in Glioblastoma Using a Polyglycerol-based Polyplex. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016, 12:2201-2214. [PDF] [PubMed]

Schwartz H, Blacher E, Amer M, Livneh N, Abramovitz L, Klein A, Ben-Shushan D, Soffer S, Blazquez R, Barrantes-Freer A, Müller M, Müller-Decker K, Stein R, Tsarfaty G, Satchi-Fainaro R, Umansky V, Pukrop T, Erez N. Incipient melanoma brain metastases instigate astrogliosis and neuroinflammation. Cancer Res. 2016. 76:4359-71 [PDF] [PubMed]

Golan M, Feinshtein V, Polyak D, Scomparin A, Satchi-Fainaro R, David A. Inhibition of Gene Expression and Cancer Cell Migration by CD44v3/6-Targeted Polyion Complexes. Bioconjug Chem. 2016. 27:947-960. [PDF] [PubMed]

Fisusi FA, Siew A, Chooi KW, Okubanjo O, Garrett N, Lalatsa K, Serrano D, Summers I, Moger J, Stapleton P, Satchi-Fainaro R, Schätzlein AG, Uchegbu IF. Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels – A Strategy for Brain Cancer Treatments, Pharmaceutical Research 2016, 33(5):1289-1303. [PDF] [PubMed]

Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y, Aviel-Ronen S, Barshack I, Calderón M, Haag R and Satchi-Fainaro R. Identification of Dormancy-Associated MicroRNAs for the Design of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes, ACS Nano 2016, 10(2): 2028-2045. [PDF] [PubMed]

2015

Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R, Caliceti P. Novel Pullulan Bioconjugate for Selective Breast Cancer Bone Metastases Treatment. Bioconjug Chem 2015, 18;26(3):489-501 [PDF][PubMed] 

Scomparin A, Salmaso S, Eldar-Boock A, Ben-Shushan D, Ferber S, Tiram G, Shmeeda H, Landa-Rouben N, Leor J, Caliceti P, Gabizon A, Satchi-Fainaro R. A comparative study of folate receptor-targeted doxorubicin delivery systems: Dosing regimens and therapeutic index. J Control Release 2015, 208 : 106–120 [PDF][PubMed] 

Redy-Keisar O, Ferber S, Satchi-Fainaro R, Shabat D. NIR Fluorogenic Dye as a Modular Platform for Prodrug Assembly: Real-Time in vivo Monitoring of Drug Release. ChemMedChem. 2015 Jun;10(6):999-1007.  [PDF][PubMed] 

2014

Dvashi Z, Shalom HJ, Shoat M, Ben-Meir D, Ferber S, Satchi-Fainaro R, Ashery-Padan R, Rosner M, Solomon AS, Lavi S, Protein phosphatase Magnesium dependent 1A governs the wound healing-inflammation-angiogenesis cross talk on injury, American Journal of Pathology, 2014, 184(11):2936-50 [PDF] [PubMed]

Ferber S, Tiram G, Satchi-Fainaro R, Monitoring functionality and morphology of vasculature recruited by factors secreted by fast-growing tumor-generating cells, The Journal of Visualized Experiments (JoVE), 2014 Nov 23;(93):e51525 . [PDF] [JoVE] [PubMed]

Markovsky E*,  Baabur-Cohen H*, Satchi-Fainaro R. Anticancer polymeric nanomedicine bearing synergistic drug combination is superior to a mixture of individually-conjugated drugs. J Control Release 2014, 187: 145-157. [PDF] [PubMed]. Editorial highlight.

*These authors contributed equally to this work.

Kisin-Finfer E, Ferber S, Blau R, Satchi-Fainaro R, Shabat D. Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action. Bioorganic & Medicinal Chemistry Letters  2014 24 (11): 2453–2458. [PDF] [PubMed] 

Ferber S*, Baabur-Cohen H*, Blau R*, Epstein Y, Kisin-Finfer E ,Redy O, Shabat D, Satchi-Fainaro R. Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release. Cancer Letters  2014 Sep 28;352(1):81-9. [PDF] [PubMed]

*These authors contributed equally to this work.

Redy-Keisar O, Kisin-Finfer E, Ferber S, Satchi-Fainaro R & Shabat D. Synthesis and use of QCy7-derived modular probes for the detection and imaging of biologically relevant analytes. Nature Protocols 2014 9 (1): 27-36. [PDF] [PubMed]

2013

Miller K, Chiara Clementi, Polyak D, Eldar-Boock A, Benayoun L, Barshack I, Shaked Y, Pasut G and Satchi-Fainaro R. Poly(ethylene glycol)-paclitaxel-alendronate Self-assembled Micelles for the Targeted Treatment of Breast Cancer Bone Metastases. Biomaterials 2013 34(15): 3795–3806.  [PDF] [Pubmed]

Benayoun L, Schaffer M, Brill R, Gingis-Velitski S, Segal E, Nevelsky A, Satchi-Fainaro R, Shaked Y, Porfimer-sodium (Photofrin-II) in combination with ionizing radiation inhibits tumor initiating cell proliferation and improves glioblastoma treatment efficacy, Cancer Biology & Therapy, 2013 14(1), 64-74. (Cover feature). [PDF] [PubMed]

Chuderland D, Ben-Ami I, Kaplan-Kraicer R, Grossman H, Komsky A, Satchi-Fainaro R, Eldar-Boock A, Ron-El R, Shalgi R, Hormonal regulation of pigment epithelium derived factor (PEDF) in granulosa cells, Molecular Human Reproduction, 2013 19(2), 72-81. [PDF] [PubMed]

Herzog IM, Feldman M, Eldar-Boock A, Satchi-Fainaro R, Fridman M, Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity, MedChemComm, 2013 4, 120-124. [PDF]

2012

Satchi-Fainaro R*, Ferber S*, Segal E, Ma L, Dixit N, Ijaz A, Hlatky L, Abdollahi A, Almog N. Prospective Identification of Glioblastoma Cells Generating Dormant Tumors. PLoS ONE 2012 7(9): e44395. [PDF] [PubMed]
*These authoainarolab.com/rs contributed equally to this work.

Benayoun L, Gingis-Velitski S, Voloshin T, Segal E, Segev E, Munster M, Bril R, Satchi-Fainaro R, Scherer SJ, and Shaked Y. Tumor Initiating Cells of Various Tumor Types Exhibit Differential Angiogenic Properties and React Differently to Antiangiogenic Drugs. Stem Cells. 2012 Sep;30(9):1831-41. [PDF] [PubMed]

Herzog IM, Green KD, Berkov-Zrihen Y, Feldman M, Vidavski RR, Eldar-Boock A, Satchi-Fainaro R, Eldar A, Garneau-Tsodikova S, Fridman M. 6”-thioether tobramycin analogues: towards selective targeting of bacterial membranes. Angew Chem Int Ed Engl. 2012 51(23):5652-6.  [PDF] [PubMed]

2011

Clementi C, Miller K, Mero A, Satchi-Fainaro R, Pasut G. Dendritic poly(ethylene glycol) bearing paclitaxel and alendronate for targeting bone neoplasms. Mol Pharm 2011, 8(4):1063-1072. [PDF] [PubMed]

Eldar-Boock A, Miller K, Sanchis J, Lupu R, Vicent MJ, Satchi-Fainaro R. Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel. Biomaterials 2011, 32(15):3862-3874. [PDF] [PubMed]

Fante C, Eldar-Boock A, Satchi-Fainaro R, Osborn HM, Greco F. Synthesis and biological evaluation of a polyglutamic acid-dopamine conjugate: a new antiangiogenic agent. J Med Chem 2011, 54(14):5255-5259. [PDF] [PubMed]

Miller K, Eldar-Boock A, Polyak D, Segal E, Benayoun L, Shaked Y, Satchi-Fainaro R. Antiangiogenic antitumor activity of HPMA copolymer-paclitaxel-alendronate conjugate on breast cancer bone metastasis mouse model. Mol Pharm 2011, 8(4):1052-1062. [PDF] [PubMed]

Scomparin A, Salmaso S, Bersani S, Satchi-Fainaro R, Caliceti P. Novel folated and non-folated pullulan bioconjugates for anticancer drug delivery. Eur J Pharm Sci 2011, 42(5):547-558. [PDF] [PubMed]

Segal E, Pan H, Benayoun L, Kopeckova P, Shaked Y, Kopecek J, Satchi-Fainaro R. Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances. Biomaterials 2011, 32(19):4450-4463. [PDF] [PubMed]

2010

Fischer W, Claderon M, Ofek P, Satchi-Fainaro R, Haag R. siRNA transfection by dendritic core-shell nanocarriers. J Control Release 2010 ,148(1):e89. [PDF] [PubMed]

Marom H, Miller K, Bechor-Bar Y, Tsarfaty G, Satchi-Fainaro R, Gozin M. Toward development of targeted nonsteroidal antiandrogen-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-gadolinium complex for prostate cancer diagnostics. J Med Chem 2010, 53(17):6316-6325. [PDF] [PubMed]

Ofek P, Fischer W, Calderon M, Haag R, Satchi-Fainaro R. In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers. FASEB J 2010, 24(9):3122-3134. [PDF] [PubMed]

Polyak, D Ryppa C, Eldar-Boock A, Ofek P, Many A, Licha K, Kratz F, Satchi-Fainaro R. Development of PEGylated doxorubicin-E-[c(RGDfK)2] conjugate for integrin-targeted cancer therapy. Polymers for Advanced Technologies 22.1 (2010): 103-113. [PDF]

Weinstain R, Segal E, Satchi-Fainaro R, Shabat D. Real-time monitoring of drug release. Chem Commun (Camb) 2010, 46(4):553-555. [PDF] [PubMed]

2009

Erez R, Segal E, Miller K, Satchi-Fainaro R, Shabat D. Enhanced cytotoxicity of a polymer-drug conjugate with triple payload of paclitaxel. Bioorg Med Chem 2009, 17(13):4327-4335. [PDF] [PubMed]

Miller K, Erez R, Segal E, Shabat D, Satchi-Fainaro R. Targeting bone metastases with a bispecific anticancer and antiangiogenic polymer-alendronate-taxane conjugate. Angew Chem Int Ed Engl 2009, 48(16):2949-2954. [PDF] [PubMed]

Ryppa C, Mann-Steinberg H, Biniossek ML, Satchi-Fainaro R*, Kratz F*. In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-[c(RGDfK)2] that targets integrin alpha v beta 3. Int J Pharm 2009, 368(1-2):89-97. [PDF] [PubMed]

*Corresponding authors

Segal E, Pan H, Ofek P, Udagawa T, Kopeckova P, Kopecek J, Satchi-Fainaro R. Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics. PLoS One 2009, 4(4):e5233. [PDF] [PubMed]

Stern L, Perry R, Ofek P, Many A, Shabat D, Satchi-Fainaro R. A novel antitumor prodrug platform designed to be cleaved by the endoprotease legumain. Bioconjug Chem 2009, 20(3):500-510. [PDF] [PubMed]

2008

Ryppa C, Mann-Steinberg H, Fichtner I, Weber H, Satchi-Fainaro R, Biniossek ML, Kratz F. In vitro and in vivo evaluation of doxorubicin conjugates with the divalent peptide E-[c(RGDfK)2] that targets integrin alphavbeta3. Bioconjug Chem 2008, 19(7):1414-1422. [PDF] [PubMed]

2007

Chesler L, Goldenberg DD, Seales IT, Satchi-Fainaro R, Grimmer M, Collins R, Struett C, Nguyen KN, Kim G, Tihan T et al. Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma. Cancer Res 2007, 67(19):9435-9442. [PDF] [PubMed]

Nahari D, Satchi-Fainaro R, Chen M, Mitchell I, Task LB, Liu Z, Kihneman J, Carroll AB, Terada LS, Nwariaku FE. Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancer. Mol Cancer Ther 2007, 6(4):1329-1337. [PDF] [PubMed]

Sagi A, Segal E, Satchi-Fainaro R*, Shabat D*. Remarkable drug-release enhancement with an elimination-based AB3 self-immolative dendritic amplifier. Bioorg Med Chem 2007, 15(11):3720-3727. [PDF] [PubMed]

*Corresponding authors

2001-2006

Becker CM, Wright RD, Satchi-Fainaro R, Funakoshi T, Folkman J, Kung AL, D’Amato RJ. A novel noninvasive model of endometriosis for monitoring the efficacy of antiangiogenic therapy. Am J Pathol 2006, 168(6):2074-2084. [PDF] [PubMed]

Javid PJ, Greene AK, Garza J, Gura K, Alwayn IP, Voss S, Nose V, Satchi-Fainaro R, Zausche B, Mulkern RV et al. The route of lipid administration affects parenteral nutrition-induced hepatic steatosis in a mouse model. J Pediatr Surg 2005, 40(9):1446-1453. [PDF] [PubMed]

Satchi-Fainaro R, Mamluk R, Wang L, Short SM, Nagy JA, Feng D, Dvorak AM, Dvorak HF, Puder M, Mukhopadhyay D et al. Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin. Cancer Cell 2005, 7(3):251-261. [PDF] [PubMed]

Tjin Tham Sjin RM, Satchi-Fainaro R, Birsner AE, Ramanujam VM, Folkman J, Javaherian K. A 27-amino-acid synthetic peptide corresponding to the NH2-terminal zinc-binding domain of endostatin is responsible for its antitumor activity. Cancer Res 2005, 65(9):3656-3663. [PDF] [PubMed]

Perino S, Contino-Pepin C, Satchi-Fainaro R, Butterfield C, Pucci B. Inhibition of angiogenesis by THAM-derived cotelomers endowed with thalidomide moieties. Bioorg Med Chem Lett 2004, 14(2):421-425. [PDF] [PubMed]

Satchi-Fainaro R, Puder M, Davies JW, Tran HT, Sampson DA, Greene AK, Corfas G, Folkman J. Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nat Med 2004, 10(3):255-261. [PDF] [PubMed]

Satchi-Fainaro R, Hailu H, Davies JW, Summerford C, Duncan R. PDEPT: polymer-directed enzyme prodrug therapy. 2. HPMA copolymer-beta-lactamase and HPMA copolymer-C-Dox as a model combination. Bioconjug Chem 2003, 14(4):797-804. [PDF] [PubMed]

Satchi-Fainaro R, Wrasidlo W, Lode HN, Shabat D. Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation. Bioorg Med Chem 2002, 10(9):3023-3029. [PDF] [PubMed]

Satchi R, Connors TA, Duncan R. PDEPT: polymer-directed enzyme prodrug therapy. I. HPMA copolymer-cathepsin B and PK1 as a model combination. Br J Cancer 2001, 85(7):1070-1076. [PDF] [PubMed]