Cancer Research and Nanomedicine Laboratory
Cancer Research and Nanomedicine Laboratory
Pozzi S, Scomparin A, Ben-Shushan D, Yeini E, Ofek P, Nahmad AD, Soffer S, Ionescu A, Ruggiero A, Barzel A, Brem H, Hyde TM, Barshack I, Sinha S, Ruppin E, Weiss T, Madi A, Perlson E, Slutsky I, Florindo HF, Satchi-Fainaro R. MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression. JCI Insight. 2022 Sep 8;7(17):e154804. doi: 10.1172/jci.insight.154804.[PDF][PubMed]
Epshtein Y, Blau R, Pisarevsky E, Koshrovski-Michael S, Ben-Shushan D, Pozzi S, Shenbach-Koltin G, Fridrich L, Buzhor M, Krivitsky A, Dey P, Satchi-Fainaro R. Polyglutamate-based nanoconjugates for image-guided surgery and post-operative melanoma metastases prevention. Theranostics. 2022 Aug 29;12(14):6339-6362. doi: 10.7150/thno.72941. eCollection 2022. [PDF] [PubMed]
Acúrcio RC, Pozzi S, Carreira B, Pojo M, Gómez-Cebrián N, Casimiro S, Fernandes A, Barateiro A, Farricha V, Brito J, Leandro AP, Salvador JAR, Graça L, Puchades-Carrasco L, Costa L, Satchi-Fainaro R, Guedes RC, Florindo HF. Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment. J Immunother Cancer. 2022 Jul;10(7):e004695. [PDF][PubMed]
Sekhar AR, Chitose Y, Janoš J, Dangoor SI, Ramundo A, Satchi-Fainaro R, Slavíček P, Klán P, Weinstain R. Porphyrin as a versatile visible-light-activatable organic/metal hybrid photoremovable protecting group. Nature Communications. 2022 Jun 24;13(1):3614. doi: 10.1038/s41467-022-31288-2. [PDF][PubMed]
Krivitsky A, Pozzi S, Yeini E, Israeli Dangoor S, Zur T, Golan S, Krivitsky V, Albeck N, Pisarevsky E, Ofek P, Madi A, Satchi-Fainaro R. Sulfonated Amphiphilic Poly(α)glutamate Amine-A Potential siRNA Nanocarrier for the Treatment of Both Chemo-Sensitive and Chemo-Resistant Glioblastoma Tumors. Pharmaceutics. 2021 Dec 20;13(12):2199.[PDF][PubMed]
Neufeld L, Yeini E, Reisman N, Shtilerman Y, Ben-Shushan D, Pozzi S, Madi A, Tiram G, Eldar-Boock A, Ferber S, Grossman R, Ram Z, Satchi-Fainaro R, Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment, Science Advances, 2021 Aug 18;7(34). [PDF][PubMed]
Yeini E, Ofek P, Pozzi S, Albeck N, Ben-Shushan D, Tiram G, Golan S, Kleiner R, Sheinin R, Reich-Zeliger S, Grossman R, Ram Z, Brem H, Hyde TM, Magod P, Friedmann-Morvinski D, Madi A and Satchi-Fainaro R, P-selectin inhibition alters microglia immunophenotype and blocks glioblastoma progression, Nature Communications, 2021 Mar 26;12(1):1912. [PDF][PubMed]
Shaashua L, Eckerling A, Israeli B, Yanovich G, Rosenne E, Fichman-Horn S, Ben Zvi I, Sorski L, Haldar R, Satchi-Fainaro R, Geiger T, Sloan EK, Ben-Eliyahu S, Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretome, BMC Biology, 2020 Nov 6;18(1):163. [PDF][PubMed]
Monteran L, Ershaid N, Sabah I, Fahoum I, Zait Y, Shani O, Cohen N, Eldar-Boock A, Satchi-Fainaro R, Erez N. Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis. Scientific Reports, 2020 Aug 14;10(1):13838. [PDF] [PubMed]
Pisarevsky E, Blau R, Epshtein Y, Ben-Shushan D, Eldar-Boock A, Tiram G, Koshrovski-Michael S, Scomparin A, Pozzi S, Krivitsky A, Shenbach-Koltin G, Yeini E, Fridrich L, White R, Satchi-Fainaro R. Rational Design of Polyglutamic Acid Delivering an Optimized Combination of Drugs Targeting Mutated BRAF and MEK in Melanoma. Advanced Therapeutics, 2020, https://doi.org/10.1002/adtp.202000028. [PDF] [Publisher]
Zinger A, Koren L, Adir O, Poley M, Alyan M, Yaari Z, Noor N, Krinsky N, Simon A, Gibori H, Krayem M, Mumblat Y, Kasten S, Ofir S, Fridman E, Milman N, Lübtow MM, Liba L, Shklover J, Shainsky-Roitman J, Binenbaum Y, Hershkovitz D, Gil Z, Dvir T, Luxenhofer R, Satchi-Fainaro R, Schroeder A. Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors. ACS Nano. 2019 Sep 20. doi: 10.1021/acsnano.9b02395. [PDF] [PubMed]
Doron H, Amer M, Ershaid N, Blazquez R, Shani O, Lahav TG, Cohen N, Adler O, Hakim Z, Pozzi S, Scomparin A, Cohen J, Yassin M, Monteran L, Grossman R, Tsarfaty G, Luxenburg C, Satchi-Fainaro R, Pukrop T, Erez N. Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis. Cell Rep. 2019 Aug 13;28(7):1785-1798. [PDF] [PubMed]
Conniot J, Scomparin A, Peres C, Yeini E, Pozzi S, Matos AI, Kleiner R, Moura LIF, Zupančič E, Viana AS, Doron H, Gois PMP, Erez N, Jung S, Satchi-Fainaro R, Florindo HF. Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators. Nat Nanotechnol. 2019 Sep;14(9):891-901. [PDF] [PubMed]
Borberg E, Zverzhinetsky M, Krivitsky A, Kosloff A, Heifler O, Degabli G, Peretz Soroka H, Satchi-Fainaro R, Burstein L, Reuveni S, Diamant H, Krivitsky V, Patolsky F. Light-Controlled Selective Collection-and-Release of Biomolecules by an On-chip Nanostructured Device. Nano Lett. 2019 Sep 11;19(9):5868-5878. [PDF] [PubMed]
Zafir-Lavie I, Sherbo S, Goltsman H, Badinter F, Yeini E, Ofek P, Miari R, Tal O, Liran A, Shatil T, Krispel S, Shapir N, Neil GA, Benhar I, Panet A, Satchi-Fainaro R. Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases. J Control Release.2018 Oct 17;291:80-89. doi: 10.1016/j.jconrel.2018.10.017. [PDF] [PubMed]
Blau R, Epshtein Y, Tiram G, Pisarevsky E, Israeli S, Yeini E, Krivitsky A, Eldar-Boock A, Ben-Shushan D, Green O, Ben-Nun Y, Merquiol E, Schwartz H, Blum G, Erez N, Grossman R, Ram Z, Shabat D, Satchi-Fainaro R, Image-Guided Surgery Using Near-Infrared Turn-ON Fluorescent Nanoprobes for Precise Detection of Tumor Margins, Theranostics, 2018 Jun (13): 3437-3460. [PDF] [Publisher]
Sainz V, Moura LIF, Peres C, Matos AI, Viana AS, Wagner AM, Vela Ramirez JE, Barata T, Gaspar M, Brocchini S, Zloh M, Peppas NA, Satchi-Fainaro R, Florindo HF. α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effectin melanoma. Acta Biomater. Acta Biomater. 2018 Aug;76:193-207. [PDF] [PubMed]
Tiram G*, Ferber S*, Ofek P, Eldar-Boock A, Ben-Shushan D, Yeini E, Krivitsky A, Blatt R, Almog N, Henkin J, Amsalem O, Yavin E, Cohen G, Lazarovici P, Lee JS, Ruppin E, Milyavsky M, Grossman R, Ram Z, Calderón M, Haag R, Satchi-Fainaro R. Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma. FASEB J. 2018 32:5835-5850. [PDF] [PubMed]
Zupančič E, Curato C, Kim JS, Yeini E, Porat Z, Viana AS, Globerson-Levin A, Waks T, Eshhar Z, Moreira JN, Satchi-Fainaro R, Eisenbach L, Jung S, Florindo HF. Nanoparticulate vaccine inhibits tumor growth via improved T cell recruitment into melanoma and huHER2 breast cancer. Nanomedicine. 2018 Apr;14(3):835-847. [PDF] [PubMed]
Gibori H, Eliyahu S, Krivitsky A, Ben-Shushan D, Epshtein Y, Tiram G, Blau R., Ofek P, Sang Lee J, Ruppin E, Landsman L., Barshack I, Golan T, Merquiol E.,Blum G, Satchi-Fainaro R. Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer. Nature Communications. 2018 Jan 2;9(1):16. [PDF] [PubMed]
Krivitsky A*, Polyak D*, Scomparin A*, Eliyahu S, Ofek P, Tiram G, Kalinski H, Avkin-Nachum S, Feiner Gracia N, Albertazzi L, Satchi-Fainaro R. Amphiphilic poly(α)glutamate polymeric micelles for systemic administration of siRNA to tumors. Nanomedicine. 2018 Feb;14(2):303-315 [PDF] [PubMed]
* These authors contributed equaly to this work
Ferber S*, Tiram G*, Sousa-Herves A, Eldar-Boock A, Krivitsky A, Scomparin A, Yeini E, Ofek P, Ben-Shushan D, Vossen LI, Licha K, Grossman R, Ram Z, Henkin J4, Ruppin E, Auslander N, Haag R, Calderón M, Satchi-Fainaro R. Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome. Elife (2017) Oct 4;6. pii: e25281. [PDF] [PubMed]
Markovsky E, Vax E, Ben-Shushan D, Eldar-Boock A, Shukrun R, Yeini E, Barshack I, Caspi R, Harari-Steinberg O, Pode-Shakked N, Dekel B, Satchi-Fainaro R. Wilms Tumor NCAM-Expressing Cancer Stem Cells as Potential Therapeutic Target for Polymeric Nanomedicine. Mol Cancer Ther. 2017 Nov;16(11):2462-2472. [PDF] [PubMed]
Zupančič E, Curato C, Paisana M, Rodrigues C, Porat Z, Viana AS, Afonso CAM, Pinto J, Gaspar R, Moreira JN, Satchi-Fainaro R, Jung S, Florindo HF. Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming. J Control Release. 2017 Jul 28;258:182-195. [PDF] [PubMed]
Alishekevitz D, Gingis-Velitski S, Kaidar-Person O, Gutter-Kapon L, Scherer SD, Raviv Z, Merquiol E, Ben-Nun Y, Miller V, Rachman-Tzemah C, Timaner M, Mumblat Y, Ilan N, Loven D, Hershkovitz D, Satchi-Fainaro R, Blum G, P Sleeman J, Vlodavsky I, Shaked Y. Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3.Cell Rep. 2016 Oct 25;17(5):1344-1356. [PDF] [PubMed]
Baabur-Cohen H, Vossen L, Krüger HR, Eldar-Boock A, Yeini E, Landa-Rouben N, Tiram G, Wedepohl S, Markovsky E, Leor J, Calderón M, Satchi-Fainaro R. In vivo comparative study of distinct polymeric architectures bearing a combination of paclitaxel and doxorubicin at a synergistic ratio. J Control Release. 2016. 257:118-131. [PDF] [PubMed]
Ofek P, Calderón M, Mehrabadi FS, Krivitsky A, Ferber S, Tiram G, Yerushalmi N, Kredo-Russo S, Grossman R, Ram Z, Haag R, Satchi-Fainaro R. Restoring the Oncosuppressor Activity of MicroRNA-34a in Glioblastoma Using a Polyglycerol-based Polyplex. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016, 12:2201-2214. [PDF] [PubMed]
Schwartz H, Blacher E, Amer M, Livneh N, Abramovitz L, Klein A, Ben-Shushan D, Soffer S, Blazquez R, Barrantes-Freer A, Müller M, Müller-Decker K, Stein R, Tsarfaty G, Satchi-Fainaro R, Umansky V, Pukrop T, Erez N. Incipient melanoma brain metastases instigate astrogliosis and neuroinflammation. Cancer Res. 2016. 76:4359-71 [PDF] [PubMed]
Fisusi FA, Siew A, Chooi KW, Okubanjo O, Garrett N, Lalatsa K, Serrano D, Summers I, Moger J, Stapleton P, Satchi-Fainaro R, Schätzlein AG, Uchegbu IF. Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels – A Strategy for Brain Cancer Treatments, Pharmaceutical Research 2016, 33(5):1289-1303. [PDF] [PubMed]
Tiram G, Segal E, Krivitsky A, Shreberk-Hassidim R, Ferber S, Ofek P, Udagawa T, Edry L, Shomron N, Roniger M, Kerem B, Shaked Y, Aviel-Ronen S, Barshack I, Calderón M, Haag R and Satchi-Fainaro R. Identification of Dormancy-Associated MicroRNAs for the Design of Osteosarcoma-Targeted Dendritic Polyglycerol Nanopolyplexes, ACS Nano 2016, 10(2): 2028-2045. [PDF] [PubMed]
Scomparin A, Salmaso S, Eldar-Boock A, Ben-Shushan D, Ferber S, Tiram G, Shmeeda H, Landa-Rouben N, Leor J, Caliceti P, Gabizon A, Satchi-Fainaro R. A comparative study of folate receptor-targeted doxorubicin delivery systems: Dosing regimens and therapeutic index. J Control Release 2015, 208 : 106–120 [PDF][PubMed]
Dvashi Z, Shalom HJ, Shoat M, Ben-Meir D, Ferber S, Satchi-Fainaro R, Ashery-Padan R, Rosner M, Solomon AS, Lavi S, Protein phosphatase Magnesium dependent 1A governs the wound healing-inflammation-angiogenesis cross talk on injury, American Journal of Pathology, 2014, 184(11):2936-50 [PDF] [PubMed]
Markovsky E*, Baabur-Cohen H*, Satchi-Fainaro R. Anticancer polymeric nanomedicine bearing synergistic drug combination is superior to a mixture of individually-conjugated drugs. J Control Release 2014, 187: 145-157. [PDF] [PubMed]. Editorial highlight.
*These authors contributed equally to this work.
Ferber S*, Baabur-Cohen H*, Blau R*, Epstein Y, Kisin-Finfer E ,Redy O, Shabat D, Satchi-Fainaro R. Polymeric nanotheranostics for real-time non-invasive optical imaging of breast cancer progression and drug release. Cancer Letters 2014 Sep 28;352(1):81-9. [PDF] [PubMed]
*These authors contributed equally to this work.
Benayoun L, Schaffer M, Brill R, Gingis-Velitski S, Segal E, Nevelsky A, Satchi-Fainaro R, Shaked Y, Porfimer-sodium (Photofrin-II) in combination with ionizing radiation inhibits tumor initiating cell proliferation and improves glioblastoma treatment efficacy, Cancer Biology & Therapy, 2013 14(1), 64-74. (Cover feature). [PDF] [PubMed]
Herzog IM, Feldman M, Eldar-Boock A, Satchi-Fainaro R, Fridman M, Design of membrane targeting tobramycin-based cationic amphiphiles with reduced hemolytic activity, MedChemComm, 2013 4, 120-124. [PDF]
Benayoun L, Gingis-Velitski S, Voloshin T, Segal E, Segev E, Munster M, Bril R, Satchi-Fainaro R, Scherer SJ, and Shaked Y. Tumor Initiating Cells of Various Tumor Types Exhibit Differential Angiogenic Properties and React Differently to Antiangiogenic Drugs. Stem Cells. 2012 Sep;30(9):1831-41. [PDF] [PubMed]
Polyak, D Ryppa C, Eldar-Boock A, Ofek P, Many A, Licha K, Kratz F, Satchi-Fainaro R. Development of PEGylated doxorubicin-E-[c(RGDfK)2] conjugate for integrin-targeted cancer therapy. Polymers for Advanced Technologies 22.1 (2010): 103-113. [PDF]
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