publications

Reviews

2021

Pozzi S, Scomparin A, Israeli Dangoor S, Rodriguez D, Ofek P, Neufeld L, Krivitsky A, Vaskovich-Koubi D, Kleiner R, Dey P, Koshrovski-Michael S, Reisman N, and Satchi-Fainaro R, Meet me halfway: Are in vitro 3D cancer models on the way to replace in vivo models for nanomedicine development? Advanced Drug Delivery Reviews, 2021 Apr 7:S0169-409X(21)00098-3. doi: 10.1016/j.addr.2021.04.001. [PDF][PubMed]

Peres C, Matos AI, Moura LIF, Acúrcio RC, Carreira B, Pozzi S, Vaskovich-Koubi D, Kleiner R, Satchi-Fainaro R*, Florindo HF*, Preclinical models and technologies to advance nanovaccine development, Advanced Drug Delivery Reviews,2021 Mar 9;172:148-182. [PDF][PubMed]

2020

Carreira B, Acúrcio RC, Matos AI, Peres C, Pozzi S, Vaskovich-Koubi D, Kleiner R, Bento M, Satchi-Fainaro R,* Florindo HF*. Nanomedicines as Multifunctional Modulators of Melanoma Immune Microenvironment. Advanced Therapeutics, 2020, 2000147. [PDF] [Publisher]

Yeini E, Ofek P, Albeck N, Rodriguez Ajamil D, Neufeld L, Eldar-Boock A, Kleiner R, Vaskovich D, Koshrovski-Michael D, Israeli Dangoor S, Krivitsky A, Burgos Luna C, Shenbach-Koltin G, Goldenfeld M, Hadad O, Tiram G, Satchi-Fainaro R. Targeting Glioblastoma: Advances in Drug Delivery and Novel Therapeutic Approaches. Advanced Therapeutics, 2020, 2000124. [PDF] [Publisher]

Florindo HF, Kleiner R, Vaskovich-Koubi D, Acúrcio RC, Carreira B, Yeini Y, Tiram G, Liubomirski Y, Satchi-Fainaro R. Immune-mediated approaches against COVID-19. Nature Nanotechnology, 2020 Jul 13:1-16. doi: 10.1038/s41565-020-0732-3. [PDF] [PubMed]

2019

Matos AI, Carreira B, Peres C, Moura LIF, Conniot J, Fourniols T, Scomparin A, Martínez-Barriocanal Á, Arango D, Conde JP, Préat V, Satchi-Fainaro R, Florindo HF. Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer. J Control Release. 2019 Aug 10;307:108-138. [PDF] [PubMed]

2018

Acúrcio R, Scomparin A, Satchi-Fainaro R, Florindo HF, Cardoso Guedes R. Computer-aided drug design in new druggable targets for the next generation of immune-oncology therapies. WIREs Comput. Mol Sci 2018, Article number e1397 DOI: 10.1002/wcms.1397. [PDF] [Link]

Acúrcio RC, Scomparin A, Conniot J, Salvador JAR, Satchi-Fainaro R, Florindo HF*, Guedes RC*, Structure-function analysis of immune checkpoint receptors to guide forthcoming multi-targeting anticancer immunotherapy, Journal of Medicinal Chemistry, 61 (24), 10957–10975 (2018). [PDF] [PubMed]

Satchi-Fainaro R. My greatest experiment. Nat Nanotechnol. 2018 Feb;13(2):176. doi: 10.1038/s41565-018-0064-8. PMID: 29403044. [PDF] [PubMed]

2017

Blau R, Neeman M, Satchi-Fainaro R. Emerging Nanomedical Solutions for Angiogenesis Regulation. Adv Drug Deliv Rev. 2017 Sep 15;119:1-2. [PDF] [PubMed]

Silva AL, Peres C, Conniot J, Matos AI, Moura L, Carreira B, Sainz V, Scomparin A, Satchi-Fainaro R, Préat V, Florindo HF. Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation. Semin Immunol. 2017 Dec;34:3-24. [PDF] [PubMed]

Scomparin A, Florindo HF, Tiram G, Ferguson EL, Satchi-Fainaro R. Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives. Adv Drug Deliv Rev. 2017 Sep 1;118:52-64. [PDF] [PubMed]

Satchi-Fainaro R, Vicent MJ, Richardson S. Professor Ruth Duncan: A Pioneer in the Field of Polymer Therapeutics, J Drug Targeting 2017 Nov – Dec;25(9-10):757-758. [PDF] [PubMed]

Ofek P, Tiram G, Satchi-Fainaro R. Angiogenesis regulation by nanocarriers bearing RNA interference. Adv Drug Deliv Rev. 2017 Sep 15;119:3-19. [PDF] [PubMed]

2016

Blau R, Krivitsky A, Epshtein Y, Satchi-Fainaro R. Are nanotheranostics and nanodiagnostics-guided drug delivery stepping stones towards precision medicine? Drug Resist Updat. 2016 Jul;27:39-58. [PDF] [PubMed]

2015

Scomparin A, Polyak D, Krivitsky A, Satchi-Fainaro R. Achieving successful delivery of oligonucleotides – From physico-chemical characterization to in vivo evaluation Biotechnol Adv. 2015 Nov 1;33(6 Pt 3):1294-309. [PDF] [PubMed]

2014

Ben-Shushan D*, Markovsky E*, Gibori H*, Tiram G, Scomparin A, Satchi-Fainaro R. Overcoming obstacles in microRNA delivery towards improved cancer therapy. Drug Deliv. and Transl. Res. 2014, 4 (1): 38-49. [PDF] [Pubmed]

Tiram G*, Scomparin A*, Ofek P, Satchi-Fainaro R. Interfering Cancer with Polymeric siRNA Nanocarriers. J. Biomed. Nanotechnol. 2014 Jan;10(1):50-66. [PDF] [PubMed]

2013

Eldar-Boock A*, Polyak D*, Scomparin A, Satchi-Fainaro R. Nano-sized polymers and liposomes designed to deliver combination therapy for cancer. Current Opinion in Biotechnology 2013, 24:682–689. [PDF] [PubMed]

*These authors equally contributed to this manuscript.

Polyak D*, Eldar-Boock A*, Baabur-Cohen H, Satchi-Fainaro R. Polymer conjugates for focal and targeted delivery of drugs. Polym. Adv. Technol. 2013, 24: 777–790. [Link] [PDF]

*These authors equally contributed to this manuscript.

2012

Markovsky E, Baabur-Cohen H, Eldar-Boock A, Omer L, Tiram G, Ferber S, Ofek P, Polyak D, Scomparin A, Satchi-Fainaro R: Administration, distribution, metabolism and elimination of polymer therapeutics. J Control Release 2012, 161(2):446-460. [PDF] [PubMed]

2010

David A, Satchi-Fainaro R. Special Theme issue: Polymer Therapeutics as novel nanomedicines, Editorial- Polymer Therapeutics—From Bench to Bedside. Israel Journal of Chemistry 2010, 50:145-146. [PDF] [Link]

Ofek P, Miller K, Eldar-Boock A, Polyak D, Segal E, Satchi-Fainaro R. Rational design of multifunctional polymer therapeutics for cancer theranostics, Special Theme issue: Polymer Therapeutics as novel nanomedicines. Israel Journal of Chemistry 2010, 50:185-203. [PDF]

2009

Segal E, Satchi-Fainaro R, Design and development of polymer conjugates as anti-angiogenic agents. Adv Drug Deliv Rev 2009, 61(13):1159-1176. [PDF] [PubMed]

2001-2006

Duncan R, Ringsdorf H, Satchi-Fainaro R. Polymer therapeutics–polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities. J Drug Target 2006, 14(6):337-341. [PDF] [PubMed]

Satchi-Fainaro R, Barnés CM: Drug Delivery Systems to Target the Tumour Vasculature and the Tumour Cell. TECHNOLOGY/INDUSTRY OVERVIEWS 2004(The Drug Delivery Companies Report Spring/Summer 2004):43-49. [PDF]

Satchi-Fainaro R. Targeting tumor vasculature: reality or a dream? J Drug Target 2002, 10(7):529-533. [PDF] [PubMed]

Duncan R, Gac-Breton S, Keane R, Musila R, Sat YN, Satchi R, Searle F. Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic. J Control Release 2001, 74(1-3):135-146. [PDF] [PubMed]

The Satchi-Fainaro Laboratory for

Cancer Research and Nanomedicine